Aging Inflammation – Understanding the Link Between Age and Chronic Inflammation

When dealing with aging inflammation, a low‑grade, persistent inflammatory state that rises as we get older, often called "inflamm‑aging", also known as inflamm‑aging, it’s crucial to see it as a system‑wide issue rather than a isolated symptom.

In practice, chronic inflammation, the continual activation of immune pathways that normally protect against injury and infection serves as the engine behind aging inflammation. Cellular senescence, a state where cells stop dividing but release pro‑inflammatory signals feeds that engine, while oxidative stress, an excess of reactive oxygen species that damages proteins, DNA and lipids turns the fuel into a corrosive blaze. The aging immune system itself, often described as immune aging, the gradual decline in immune surveillance and regulation, struggles to clear senescent cells and dampen oxidative damage, creating a feedback loop where each factor amplifies the others.

Put simply, aging inflammation encompasses chronic inflammation, cellular senescence contributes to aging inflammation, oxidative stress amplifies immune aging, and immune aging weakens the body’s ability to control inflammation. This cascade explains why older adults face higher risks of heart disease, neuro‑degeneration, arthritis and frailty. Understanding these connections lets you spot where lifestyle tweaks, dietary antioxidants or targeted therapies might break the cycle.

Below you’ll find a curated set of articles that dive into specific drugs, supplements, and lifestyle strategies that intersect with these mechanisms. From how certain antibiotics influence gut‑driven inflammation to the role of hormonal balance in senescent cell clearance, the collection offers practical insights you can apply right away.