Tag: QT prolongation

Dofetilide and Cimetidine: Why This Drug Pair Can Trigger Life-Threatening Arrhythmias

Dofetilide and Cimetidine: Why This Drug Pair Can Trigger Life-Threatening Arrhythmias

Nov 19 2025 / Medications

Dofetilide and cimetidine together can cause life-threatening heart rhythms due to a dangerous drug interaction that spikes dofetilide levels. Learn why this combo is strictly contraindicated and what safer alternatives exist.

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